Development of a New Distyrylbenzene-Derivative Amyloid-β-aggregation and Fibril Formation Inhibitor

Molecular mechanisms initiating amyloid β-fibril formation in Alzheimer’s disease

decline characteristic of AD. Therefore, a detailed knowledge of Aβ assembly is crucial for the development of new therapeutic approaches designed to prevent fibril formation and/or to dissociate existing fibrils. Yet, our understanding of the molecular mechanisms underlying the initiation of Aβ fibrillogenesis remains very incomplete. Amyloid β-peptide is produced by specific endoproteolytic c...

Sucrose modulates insulin amyloid-like fibril formation: effect on the aggregation mechanism and fibril morphology†

Surface-catalyzed amyloid fibril formation.

Light chain (or AL) amyloidosis is characterized by the pathological deposition of insoluble fibrils of immunoglobulin light chain fragments in various tissues, walls of blood vessels, and basement membranes. In the present investigation, the in vitro assembly of a recombinant amyloidogenic light chain variable domain, SMA, on various surfaces was monitored using atomic force microscopy. SMA fo...

Pathways and intermediates of amyloid fibril formation.

The lack of understanding of amyloid fibril formation at the molecular level is a major obstacle in devising strategies to interfere with the pathologies linked to peptide or protein aggregation. In particular, little is known on the role of intermediates and fibril elongation pathways as well as their dependence on the intrinsic tendency of a polypeptide chain to self-assembly by beta-sheet fo...

Synthesis and biological assessment of 2-hydroxyiminoethanones as anti-inflammatory and β-amyloid aggregation inhibitors

Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are a major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b ...